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Fallout 76 Perkopedia Endurance Tier List and All Perks Explained. Detailed Guide.

TheArenaUncensored: Man these series are great

zumbazumba1: Easiest way to make disease cure is by all means forest disease cure (they are separated by regions in which you collect plants).You unlock plans at level 1 .You need firecap mushroom which grows from The Wayward up to morgan town trainyard-just follow the railroad and around the river its a bright orange mushroom you cant miss it.

Snaptail reed grows around river north of wayward also a lot of it can be found if you follow river south of wayward.

Bloodleaf can be found as well south of wayward by the river or on Spruce knob lake south of Foundation.

Combine those three and you get disease cure -remember to use green thumb and super duper perk cards!

Saltzgrave: I've found Radiation Power is manageable with single shot weapons that have a slow rate of fire. It still eats glow but pretty slowly, not bad if you can fit it in a build. Though I do use thru hiker and carry 1000 toxic goo on me all the time. With the new 3 star in Burning Springs that restores glow on kill and a weapon that one or two shots most enemies, it'll likely keep itself level if you're not getting hit

Dmaster2k: I like that Ironclad works on full body armors like the Chinese Stealth Suit, getting an extra 30% armor from one point is really nice.

ChuggaMugga69: It’s valid to argue chem fiend is a definite s tier cause intelligence can be used as a combat buff now so it’s not just for xp

mnemic321_2: Cannibal gives rads for ghouls good for quick rads if needed

jackharrison9756: I had no clue starched genes wasn’t needed for a goul

bigsmoke167: Rad Sponge is S tier for trolling capabilities on bloodied players

GingerJ73: Thanks Turtle - good to highlight only rank 3 bullet shield from next patch. I see so many other YouTubers doing various gauss mini or peppershaker build video’s recently and almost none of them mention this! Cheers

chaoticinfamy6462: I will say combining vaccinated and company tea with herbivore mutation and strange in numbers does make it to where you cant catch a disease. I was catching diseases pretty often in the raid which would shut off natural resistances, thrist quencher, and iron stomach for me. slotted in vaccinated and keep my tea up every hour and I havnt caught a disease since

zero_senpai4396: There is a Mutation for out of combat health regen so Perk card useless as twice)

MrSnivvel: Cannibal is S tier for Ghouls because of the Rads you get from an limitless supply of munchies.

ogdred4667: To think that END used to be such a worthless SPECIAL, now look at where it is. Such good changes.

pet666ful: Did i miss some bethesda spaghetti code or Homebody's well rested bonus do nothing for Rejuvenator's 4 star?

dualfallen: Charisma's up next, interested to see how that goes, so many of those perks are so bad

Hoping you do Legendary Perks at the end of all this

beastabuelos6421: No joke, when i have low levels on my team, i will equip and share photosynthetic to heal them. I'd do the same with sun kissed when playing as a human. D tier from me lol.

Oh yea, ghouls can use human only perks that are shared, or at least thirst quencher works. I wonder if ghoul perks work for humans when shared

EleshNorn-ui1eg: I am a rejouvenators power armor build and I didn't know about home body. I went and tested it and I dont understand what benefits it gives for rejouvenators. Outside of camp it doesn't seem to be doing anything. What am I missing? Also I use vaccinated in my raid build because of all the endurance perks and I never get a disease without it. The crystals part I almost always get a disease without it. I could probably do without it but it's such a good quality of life thing and you don't have to worry about all your perks shutting off while dealing with the mole miner. But I can see the reasoning behind not using it.

walterbison: There is NO way Radicool is S-tier when it's totally useless to anyone who isn't low health...which is most players.

Poke-ladd: I think all night long stacks with nuka dark but unless I'm wrong, I swear with the current set up it can last like 5-6 minutes which can be useful for ending a fight

Still wish alcohol duration was longer though like I think base should be 5 minutes

Myrune1: Thank you for posting this series. I for one appreciate the knowledge dump and the format you provide it to us.

ShadowShaBoink: Blood sucker is really only useful for specifically human

wrayk: Tankiness isn't needed outside of the raid, so my daily driver perk setup has low END.

sunshinevalley3369: Shared Cannibal perk is S tier in trolling

Random.76867: Mix the all night long with nuca dark because it goes to 6 times the positives

erhablablam: I can't see the 18 to my luck when I drink Nuka Cola Dark..

Am I the only one ?

Nov 26 2025

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